Varenicline and cardiovascular adverse events: a perspective review
نویسندگان
چکیده
منابع مشابه
Varenicline and Adverse Cardiovascular Events: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
BACKGROUND Varenicline is an efficacious smoking-cessation drug. However, previous meta-analyses provide conflicting results regarding its cardiovascular safety. The publication of several new randomized controlled trials (RCTs) provides an opportunity to reassess this potential adverse drug reaction. METHODS AND RESULTS We searched MEDLINE, EMBASE, and the Cochrane Library for RCTs that comp...
متن کاملRisk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis.
BACKGROUND There have been postmarketing reports of adverse cardiovascular events associated with the use of varenicline, a widely used smoking cessation drug. We conducted a systematic review and meta-analysis of randomized controlled trials to ascertain the serious adverse cardiovascular effects of varenicline compared with placebo among tobacco users. METHODS We searched MEDLINE, EMBASE, t...
متن کاملVarenicline, smoking cessation, and neuropsychiatric adverse events.
OBJECTIVE In 2009, the U.S. Food and Drug Administration issued a black box warning for varenicline regarding neuropsychiatric events. The authors used data from randomized controlled trials and from a large Department of Defense (DOD) observational study to assess the efficacy and safety of varenicline. METHOD The authors reanalyzed data from the 17 placebo-controlled randomized controlled t...
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BACKGROUND Major depression or deterioration of previous mood disorders is a common adverse consequence of coronary heart disease, heart failure, and cardiac revascularization procedures. Therefore, treatment of depression is expected to result in improvement of mood condition in these patients. Despite demonstrated effects of anti-depressive treatment in heart disease patients, the use of some...
متن کاملAssociation between antipsychotics and cardiovascular adverse events: A systematic review.
Objective: Determine whether there is an association between the risk of cardiovascular adverse events and the use of antipsychotic agents. Method: Analysis of original articles retrieved from the following databases: LILACS, PubMed, Cochrane Controlled Trials Clinical Data Bank (CENTRAL) and PsycINFO, without language restriction, dated until November 2015. After screening of 2,812 studies,...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Drug Safety
سال: 2014
ISSN: 2042-0986,2042-0994
DOI: 10.1177/2042098614530421